This manuscript reports on a landmark symposium on the ethical, legal and technical challenges of xenotransplantation in the UK. King’s College London, with endorsement from the British Transplantation Society (BTS), and the European Society of Organ Transplantation (ESOT), brought together a group of experts in xenotransplantation science, ethics and law to discuss the ethical, regulatory and technical challenges surrounding translating xenotransplantation into the clinical setting. The symposium was the first of its kind in the UK for 20 years. This paper (...) summarises the content of the expert lectures showcasing the progress which has been made in xenotransplantation including—the history of xenotransplantation, advances in gene edited animals and progress towards clinical xenotransplantation. We then set out the ethical and legal issues still to be resolved. Finally, we report the themes of the roundtable discussion highlighting areas of consensus and controversy. While the detail of the legal discussion was directed towards the UK, the principles and summary reported here are intended to be applicable to any jurisdiction seeking to implement clinical xenotransplantation. (shrink)

The target article skillfully evaluates data on mental disorders in relation to predictions from evolutionary genetic theories of neutral evolution, balancing selection, and polygenic mutation-selection balance, resulting in a negative outlook for the likelihood of success finding genes for mental disorders. Nevertheless, new conceptualizations, methods, and continued interactions across disciplines provide hope.

We explore ways in which purely qualitative belief change in the AGM tradition throws light on options in the treatment of conditional probability. First, by helping see why it can be useful to go beyond the ratio rule defining conditional from one-place probability. Second, by clarifying what is at stake in different ways of doing that. Third, by suggesting novel forms of conditional probability corresponding to familiar variants of qualitative belief change, and conversely. Likewise, we explain how recent work on (...) the qualitative part of probabilistic inference leads to a very broad class of 'proto-probability' functions. (shrink)

Participants with posttraumatic stress disorder and participants with a trauma but without PTSD wrote narratives of their trauma and, for comparison, of the most-important and the happiest events that occurred within a year of their trauma. They then rated these three events on coherence. Based on participants’ self-ratings and on naïve-observer scorings of the participants’ narratives, memories of traumas were not more incoherent than the comparison memories in participants in general or in participants with PTSD. This study comprehensively assesses narrative (...) coherence using a full two by two design. The results are counter to most prevalent theoretical views of memory for trauma. (shrink)

Interdisciplinary studies has grown significantly in the last 25 years. The reductionisms of secular modernism and postmodem relativism present an opportunity for an approach to interdisciplinary faith-learning integration that provides a unifying basis for research addressing major challenges. An approach developed at Oxford Graduate School offers promise for interdisciplinary studies comprehensive enough to bridge the three cultures of the natural, social, and humane sciences in the service of bettering the world. The Learning... to Change the World methodology proceeds through seven (...) stages: problem clarification, literature review, faith-learning integration, interdisciplinary research, contextualization, ethical/social leadership, and lifelong learning evaluation. Grounded in a Creation-Fall-Redemption-Consummation metaphysical worldview, it assumes a critical realist epistemology to engage real-world challenges. The process accommodates multiple research methods and aims for a redemptive-ethical transformation of social problems. (shrink)

A connectionist approach to word reading, based on the principles of distributed representation, graded learning of statistical structure, and interactivity in processing, has led to the development of explicit computational models which account for a wide range of data on normal skilled reading and on patterns of reading impairment due to brain damage. There have, however, been recent empirical challenges to these models, and the approach in general, relating to the influence of orthographic length on the naming latencies of both (...) normal and dyslexic readers. The current work presents a simulation which generates sequential phonological output in response to written input, and which can refixate the input when encountering difficulty. The normal model reads both words and nonwords accurately, and exhibits an effect of orthographic length and a frequency‐by‐consistency interaction in its naming latencies. When subject to peripheral damage, the model exhibits an increased length effect that interacts with word frequency, characteristic of letter‐by‐letter reading in pure alexia. Although the model is far from a fully adequate account of all the relevant phenomena, it suggests how connectionist models may be extended to provide deeper insight into sequential processes in reading. (shrink)

List of contributors; Acknowledgments; Introduction Robert S. Westman and David C. Lindberg; 1. Conceptions of the scientific revolution from Bacon to Butterfield: a preliminary sketch David C. Lindberg; 2. Conceptions of science in the scientific revolution Ernan McMullin; 3. Metaphysics and the new science Gary Hatfield; 4. Proof, portics, and patronage: Copernicus’s preface to De revolutionibus Robert S. Westman; 5. A reappraisal of the role of the universities in the scientific revolution John Gascoigne; 6. Natural magic, hermetism, and (...) occultism in early modern science Brian P. Copenhaver; 7. Natural history and the emblematic world view William B. Ashworth, Jr.; 8. From the secrets of nature to public knowledge William Eamon; 9. Chemistry in the scientific revolution: problems of language and communication Jan V. Golinski; 10. The new philosophy and medicine in seventeenth-century England Harold J. Cook; 11. Science and heterodoxy: an early modern problem reconsidered Michael Hunter; 12. Infinitesimals and transcendent relations: the mathematics of motion in the late seventeenth century Michael S. Mahoney; 13. The case of mechanics: one revolution or many? Alan Gabbey; Index. (shrink)

Reviews the connections between different kinds of nonmonotonic logic and the general idea of varying degrees of belief.

In philosophy of aesthetics, scholars commonly express a commitment to the premise that there is a distinctive type of judgment that can be meaningfully labeled “aesthetic”, and that these judgments are distinctively different from other types of judgments. We argue that, within an Aristotelian framework, there is no clear avenue for meaningfully differentiating “aesthetic” judgment from other types of judgment, and, as such, we aim to question the assumption that aesthetic judgment does in fact constitute a distinctive kind of judgment (...) that is in need of, or can be subject to, distinctive theorizing. We advance our argument primarily through demonstrating that leading contemporary accounts of aesthetic judgment do not successfully distinguish a type of judgment in that they do not tell us how making an aesthetic judgment differs substantially from judging that 2 + 3 = 5, that football is entertaining, or that today is Tuesday. (shrink)

To provide the three-way comparisons needed to test existing theories, we compared (1) most-stressful memories to other memories and (2) involuntary to voluntary memories (3) in 75 community dwelling adults with and 42 without a current diagnosis of posttraumatic stress disorder (PTSD). Each rated their three most-stressful, three most-positive, seven most-important and 15 word-cued autobiographical memories, and completed tests of personality and mood. Involuntary memories were then recorded and rated as they occurred for 2 weeks. Standard mechanisms of cognition and (...) affect applied to extreme events accounted for the properties of stressful memories. Involuntary memories had greater emotional intensity than voluntary memories, but were not more frequently related to traumatic events. The emotional intensity, rehearsal, and centrality to the life story of both voluntary and involuntary memories, rather than incoherence of voluntary traumatic memories and enhanced availability of involuntary traumatic memories, were the properties of autobiographical memories associated with PTSD. (shrink)

The sciences use a wide range of visual devices, practices, and imaging technologies. This diversity points to an important repertoire of visual methods that scientists use to adapt representations to meet the varied demands that their work places on cognitive processes. This paper identifies key features of the use of visualization in a range of scientific domains and considers the implications of this repertoire for understanding scientists as cognitive agents.

In a morally fragmented society there is no good reason for ethics committees to assume any particular point of view, yet failure to do so compromises their ability to function in either a case‐review or an educational capacity. A casuist methodology might enable committees to fulfill both roles.

The problem of developing a moral philosophy of medicine is explored in this essay. Among the challenges posed to this development are the general mistrust of moral philosophy and philosophy in general created by post-modernist philosophical and even anti-philosophical thinking. This reaction to philosophical systematization is usually called antifoundationalism. I distinguish different forms of antifoundationalism, showing that not all forms of their opposites, foundationalism, are alike, especially with regards to claims made about the certitude of moral thought. I conclude that (...) we are correct to mistrust absolutist principles in a moral philosophy of medicine, but can find some center within the practice of medicine itself for a moral foundation. (shrink)

Past ages of medical care are condemned in modern philosophical and medical literature as being too paternalistic. The normal account of good medicine in the past was, indeed, paternalistic in an offensive way to modern persons. Imagine a Jean Paul Sartre going to the doctor and being treated without his consent or even his knowledge of what will transpire during treatment! From Hippocratic times until shortly after World War II, medicine operated in a closed, clubby manner. The knowledge learned in (...) medicine was not shared with the patients, who were in general poorly educated and for the most part completely ignorant of the craft of medicine and the physicians (but not, perhaps, of folk medicine). Physicians were cautioned against telling patients too much about their Illness and/or their recovery, perhaps because physicians themselves did not have an enormous armamentarium to confront disease. (shrink)

Increasingly, the world seems to shrink due to our ever-expanding technological and communication capacities. Correspondingly, our awareness of other cultures increases. This is especially true in the field of bioethics because the technological progress of medicine throughout the world is causing dramatic and challenging intersections with traditionally held values. Think of the use of pregnancy monitoring technologies like ultrasound to abort fetuses of the “wrong” sex in India, the sale of human organs in and between countries, or the disjunction between (...) the haves and the have-nots in South America when it comes to bone marrow transplants, while thousands of other children die for want of fundamental goods and services like clean water, basic inoculations, and food itself. (shrink)

Sexual selection traditionally involves male-male competition and female choice, but in some species, including humans, sexual selection can also involve female-female competition and male choice. The degree to which one aspect of sexual selection or another is manifest in human populations will be influenced by a host of social and ecological variables, including the operational sex ratio. These variables are discussed in connection with the relative contribution of sexual selection and the division of labor to the evolution of human sex (...) differences. (shrink)

Medical ethics is a footnote to the larger problem of directing our technology to good human ends. Written large, then, medical ethics must ask five basic questions.

Considerable debate has occurred about the proper role of philosophers when offering ethics consultations. Some argue that only physicians or clinical experienced personnel should offer ethics consultations in the clinical setting. Others argue still further that philosophers are ill-equipped to offer such advice, since to do so rests on no social warrant, and violates the abstract and neutral nature of the discipline itself.I argue that philosophers not only can offer such consultations but ought to. To be a bystander when one's (...) discipline does offer insights and methods of value discernment is pusillanimous. But this position requires a view of clinical medical ethics as one that arises out of the clinical practice of medicine, and not just from an application of general ethical principles to the practice of medicine. I conclude with some skills that trained philosophers can bring to the consultation service, and note that all consultations are in the form of recommendations that the patient, family, and physician are still free to accept or reject. Philosophers in the clinical setting do not make decisions. (shrink)

: Faraday is often described as an experimentalist, but his work is a dialectical interplay of concrete objects, visual images, abstract, theoretically-informed visual models and metaphysical precepts. From phenomena described in terms of patterns formed by lines of force he created a general explanation of space-filling systems of force which obey both empirical laws and principles of conservation and economy. I argue that Faraday's articulation of situated experience via visual models into a theory capable of verbal expression owed much to (...) his strategy of moving—via conjectural visual models—between the phenomenology of particulars (often displayed as patterns) and the general features of dynamical phenomena which he depicted as structures. (shrink)

It is argued that there is a role for the representational conception of vision, and that this is compatible with the task-level account advocated by Pessoa et al. However, the role of representations must be understood independently of our conscious experience of vision.

Plagiarism has been a long standing concern within higher education. Yet with the rapid rise in the use and availability of the Internet, both the research literature and media have raised the notion that the online environment is accelerating the decline in academic ethics. The majority of research that has been conducted to investigate such claims have involved self-report data from students. This study sought to collect empirical data to investigate the potential influence the prevalence of the Internet has had (...) on significant higher education artifacts by comparing dissertations written prior to widespread use of the Internet with those written in a period in ubiquitous Internet use. Due to the prestige associated with the doctoral degree and the fact that the majority of the effort necessary to achieve such a degree resides within the dissertation, this study utilized Doctor of Philosophy dissertations written in English and published by accredited universities in the U.S. and Canada. A sample of 384 dissertations were analyzed by Turnitin plagiarism detection software. The mean similarity indices for pre-Internet and post-Internet eras were 14.5 and 12.3 %, respectively. A Mann Whitney U test indicated that the differences between groups was significant, however opposite than has been purported within the exigent literature. When comparing the counts of dissertations for each time era considering those with plagiarism versus those that had little/no evidence thereof, there was no statistically significant difference. The findings of this study suggest that the Internet may not be significantly impacting the prevalence of plagiarism in advanced levels of higher education. (shrink)